Fig. 6

a Average percent survival of axotomized FMN relative to control ± SEM at 28 dpo in WT, RAG-2^-/-, and RAG-2^-/- reconstituted with Il10rb^-/- CD4+ T cells. Survival in both RAG-2^-/- and RAG^-/- reconstituted with Il10rb^-/- CD4+ T cells was decreased relative to WT, indicating that Il10rb^-/- T cells fail to confer neuroprotection. *p < 0.05, **p < 0.01. b IHC showing CD3+ T cells in WT splenic follicles. c CD3+ cells are absent in RAG-2^-/- spleens. d Adoptive transfer of Il10rb^-/- CD4+ T cells restores CD3+ expression in splenic follicles, indicating that Il10rb^-/- CD4+ T cells were successfully transplanted and remain viable in vivo until 28 dpo. Scale bar = 100 μm and applies to b–d