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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: CD4+ T cell expression of the IL-10 receptor is necessary for facial motoneuron survival after axotomy

Fig. 6

a Average percent survival of axotomized FMN relative to control ± SEM at 28 dpo in WT, RAG-2-/-, and RAG-2-/- reconstituted with Il10rb-/- CD4+ T cells. Survival in both RAG-2-/- and RAG-/- reconstituted with Il10rb-/- CD4+ T cells was decreased relative to WT, indicating that Il10rb-/- T cells fail to confer neuroprotection. *p < 0.05, **p < 0.01. b IHC showing CD3+ T cells in WT splenic follicles. c CD3+ cells are absent in RAG-2-/- spleens. d Adoptive transfer of Il10rb-/- CD4+ T cells restores CD3+ expression in splenic follicles, indicating that Il10rb-/- CD4+ T cells were successfully transplanted and remain viable in vivo until 28 dpo. Scale bar = 100 μm and applies to bd

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