Fig. 8

Age-related gene-expression and variation between AD (12 months) and WT (12 months) mice. a–d (left), Heatmap represent the age-up microglial gene (a); age-down microglial gene (b); age-up astrocyte gene (c), and age-down astrocyte gene at 5 time points WT/AD samples. Z scores are calculated from gene FPKM values (upregulation in red, downregulation in blue, neutral in white). a–d (right), Age-up microglial gene (a); age-down microglial gene (b); age-up astrocyte gene (c), and age-down astrocyte gene (d) expression between AD (12 months) and WT (12 months) samples. Log₂ fold-change based on RNA-seq data, between 12-month AD and 12-mo WT mice; *adjusted p < 0.05, |log₂ fold-change| > 0.5. c and d (right) Only genes that exhibited statistically significant changes in expression are shown