Skip to main content
Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Normalization of magnesium deficiency attenuated mechanical allodynia, depressive-like behaviors, and memory deficits associated with cyclophosphamide-induced cystitis by inhibiting TNF-α/NF-κB signaling in female rats

Fig. 2

Decreased Mg2+ in the serum and CSF of CYP-induced cystitis animals was reversed by L-TAMS treatment. Free concentrations of Mg2+ in the serum (a) and CSF (b) of CYP-induced cystitis animals were assessed on day 8, day 12, and day 20 after the first CYP injection. n = 7 per group for serum and n = 5 per group for CSF. c, d After treatment with L-TAMS or vehicle, measurement of Mg2+ in cystitis animals was also performed on day 20. n = 10 per group for serum and n = 9 per group for CSF. **P < 0.05, **P < 0.01, and ***P < 0.001 vs. Veh group. #P < 0.05 and ###P < 0.001 vs. CYP group. The data were analyzed by one-way ANOVA followed by the Tukey post hoc test. Concentrations of Mg2+ in the serum (e–g) and CSF (h–j) of cystitis rats were correlated with floating time in the FST and the short-term memory index in the NORT. n = 13 to 15 per group. The data in e–j were analyzed by linear regression, and the correlation coefficients were calculated

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094