Fig. 2

Parametric images of distribution volume (V_T) showing [¹¹C]MC1 uptake before (top row) and on day 1 (middle row) after the first lipopolysaccharide (LPS) injection in monkey 2, followed by pharmacological blockade by MC1 (0.3 mg/kg, i.v.) on the same day (bottom row). LPS increased [¹¹C]MC1 uptake globally, which was blocked by cold parent. Orthogonal cross-hairs show the injection site, right putamen. The blockade by MC1 was incomplete—i.e., 78% according to the Lassen plot (Fig. 4). Thus, higher doses of MC1 would have caused even greater blockade