Fig. 7

APC366 improved long-term spatial learning memory after ACA. a Effect of APC366 on escape latency and swimming distance of the Morris water maze test. b Representative heatmaps, quantification of probe quadrant duration, and swimming velocities in the probe trial of the Morris water maze test. ACA was associated with prolonged escape latency and swim distance in vehicle-treated animals compared to the sham group, which was markedly improved following APC366 treatment. APC366 treatment also significantly increased probe quadrant duration that was remarkably decreased in the ACA + vehicle group compared to the sham group in the probe trial. There was no significant difference among groups in swim velocity. Data are expressed as mean ± SD. n = 6/group. ANOVA, Tukey. **p < 0.001 compared to sham, *p < 0.05 compared to sham, &&p < 0.001 compared to ACA + vehicle, &p < 0.05 compared to ACA + vehicle