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Table 3 Associations between plasma biomarkers and neuroimaging indicators

From: Plasma neurofilament light chain and glial fibrillary acidic protein predict stroke in CADASIL

  Fazekas score (n = 57)Lacunes (n = 57)CMBs (n = 47)
NfLρ (95% CI)*0.02 (− 0.26, 0.29)0.09 (− 0.19, 0.36)0.32 (0.03, 0.56)
β (95% CI)0.03 (− 0.14, 0.19)0.09 (− 0.17, 0.35)0.16 (0.02, 0.30)
GFAPρ (95% CI)*0.23 (− 0.05, 0.47)− 0.07 (− 0.34, 0.21)0.37 (0.08, 0.60)
β (95% CI)0.05 (− 0.13, 0.23)− 0.03 (− 0.31, 0.25)0.15 (− 0.02, 0.33)
Tauρ (95% CI)*− 0.08 (− 0.35, 0.20)0.08 (− 0.20, 0.34)0.08 (− 0.23, 0.36)
β (95% CI)− 0.01 (− 0.19, 0.18)0.07 (− 0.21, 0.35)0.08 (− 0.08, 0.24)
UCHL1ρ (95% CI)*0.01 (− 0.27, 0.29)− 0.13 (− 0.39, 0.16)0.08 (− 0.23, 0.36)
β (95% CI)0.02 (− 0.15, 0.20)− 0.13 (− 0.41, 0.14)0.06 (− 0.10, 0.21)
  1. Numbers in bold indicate statistical significance
  2. CMBs cerebral microbleeds, GFAP glial fibrillary acidic protein, NfL neurofilament light chain, UCHL1 ubiquitin carboxy-terminal hydrolase L1
  3. *Spearman’s rank correlation partially adjusted for age and sex. Multiple linear regression analysis adjusted for age, sex, and hypertension