Fig. 6

Anti-IL-20 mAb 7E improved spinal cord tissue preservation and reduced glial scar formation. a Luxol fast blue (LFB) stain was used to identify myelinated tissues in SCI control rats and in SCI rats treated with anti-IL-20 mAb 7E (10 mg/kg) at 28 days post-SCI (N = 5/group). Scale bars = 500 μm. b Quantification of LFB stained areas. *P < 0.05, ***P < 0.001 compared with the SCI rats. Data are expressed as mean ± SD. Data from one representative experiment of three independent experiments is shown. c At 28 days post-SCI, spinal cord tissue samples from SCI control rats and from SCI rats treated with anti-IL-20 mAb 7E (10 mg/kg) were stained with anti-chondroitin sulfate proteoglycan (CSPG) mAb to evaluate glial scar formation (N = 5/group). Scale bars = 500 μm. d Quantification of CSPG-positive stained areas. *P < 0.05 compared with the SCI rats. Data are expressed as mean ± SD. Data from one representative experiment of three independent experiments is shown