Fig. 2

CSF1R KD resulted in a sustained knockdown in diabetic animals 3 weeks post-stroke and 5 weeks post-injection. a–c Depicts representative images of IBA-1+ cells in the PFC of slice B for NTC, CSF1R KD, and sham animals, respectively. d The PFC of diabetic animals have more IBA-1+ cells 3 weeks after a stroke. However, CSF1R KD lowered this upregulation. e Like the PFC, the limbic structures of diabetic animals also have more IBA-1+ cells 3 weeks after a stroke. One-CSF1R KD lowered this upregulation but still remained higher compared to the shams (N = 5–7/group)