Fig. 8

Glybenclamide ameliorates P + M-induced LC/NE neurodegeneration and α-synuclein aggregation in mice. a LC/NE neurons were immunostained with anti-TH antibody in P + M-treated mice with or without glybenclamide, and the representative images were shown. b The number of THir neurons in the LC was counted. c The expression of α-synuclein in the brainstem of P + M-treated mice with or without glybenclamide was detected by using Western blot, and the representative blots were shown. GAPDH was used as an internal control. d The band density of blots was quantified. n = 6 for each group. *p < 0.05, **p < 0.01