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Table 4 Immunoglobulin class response patterns in MOG-IgG-positive EM

From: Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 1: Results from 163 lumbar punctures in 100 adult patients

  Units Total Attack Remission Acute MY subgroup Acute ON subgroup Acute BRAIN subgroup
a. Based on QIg > Qlim(Ig)
3-class reaction Samples 1/107 (0.9%) 1/81 (1.2%) 0/19 (0%) 1/38 (2.6%) 0/36 (0%) 0/6 (0%)
2-class reaction Samples 5/107 (4.7%) 4/81 (4.9%) 1/19 (5.3%) 2/38 (5.3%) 2/36 (5.6%) 0/6 (0%)
 IgG + IgM Samples 3/107 (2.8%) 3/81 (3.7%) 0/19 (0%)    
 IgG + IgA Samples 2/107 (1.9%) 1/81 (1.2%) 1/19 (5.3%)    
 IgM + IgA Samples 0/107 (0%) 0/81 (0%) 0/19 (0%)    
1-class reaction Samples 15/107 (14%) 15/81 (18.5%) 0/19 (0%) 10/38 (26.3%) 3/36 (8.3%) 2/6 (33.3%)
 Only IgG Samples 4/107 (3.7%) 4/81 (4.9%) 0/19 (0%)    
 Only IgM Samples 9/107 (8.4%) 9/81 (11.1%) 0/19 (0%)    
 Only IgA Samples 2/107 (1.9%) 2/81 (2.5%) 0/19 (0%)    
b. Based on Ig-IF > 10%
3-class reaction# Samples 1/107 (0.9%) 1/81 (1.2%) 0/19 (0%) 1/38 (2.6%) 0/36 (0%) 0/6 (0%)
2-class reaction§ Samples 1/107 (0.9%) 1/81 (1.2%) 0/19 (0%) 1/38 (2.6%) 0/36 (0%) 0/6 (0%)
 IgG + IgM Samples 1/107 (0.9%) 1/81 (1.2%) 0/19 (0%)    
 IgG + IgA Samples 0/107 (0%) 0/81 (0%) 0/19 (0%)    
 IgM + IgA Samples 0/107 (0%) 0/81 (0%) 0/19 (0%)    
1-class reaction Samples 9/107 (8.4%) 8/81 (9.9%) 1/19 (5.3%) 3/38 (7.9%) 4/36 (11.1%) 1/6 (16.7%)
 Only IgG Samples 3/107 (2.8%) 3/81 (3.7%) 0/19 (0%)    
 Only IgM Samples 4/107 (3.7%) 4/81 (4.9%) 0/19 (0%)    
 Only IgA Samples 2/107 (1.9%) 1/81 (1.2%) 1/19 (5.3%)    
  1. #IF in the single sample with a three-class reaction: IgG-IF 18.79%, IgM-IF 21.65% and IgA-IF 31%
  2. §IF in the single sample with a two-class reaction: IgG-IF 33.09% and IgM-IF 59%