Skip to main content

Table 8 CSF findings and attack severity

From: Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 1: Results from 163 lumbar punctures in 100 adult patients

  Units Severe attacks Mild/moderate attacks p value
WCC, all Cells/μl 43.3 (0-410; 35) 7 (0-463;83) 0.0005
WCC, elevated Samples 28/35 (80%) 44/83 (53%) 0.007
WCC, if elevated Cells/μl 47 (6-410; 28) 24 (6-463;44) n.s.
Neutrophils, all LPs Samples 8/17 (47.1%) 18/40 (45%) n.s.
OCB, pattern 2 or 3 Samples 5/32 (15.6%) 7/78 (9%) n.s.
Link index Samples 5/30 (16.7%) 4/68 (5.9%) n.s.
QIgG, all Ratio 4.2 (0.9-23.6; 30) 3.2 (1.1-14.1; 69) 0.012
QIgG, elevated Samples 4/30 (13.3%) 5/69 (7.2%) n.s.
QIgG, if elevated Ratio 4.7 (2.3-6; 4) 4.5 (2.4-7; 5) n.s.
QAlb, all Ratio 7.9 (3.2-32.7; 30) 5.7 (3-26.3; 74) 0.009
QAlb, elevated Samples 20/30 (66.7%) 29/74 (39.2%) 0.017
QAlb, if elevated Ratio 10.8 (6.5-32.7; 20) 8.3 (5.5-26.3; 29) 0.014
CSF TP, all mg/dl 55.1 (20.5-176; 31) 41.4 (20.4-171.8; 77) 0.026
CSF TP, elevated Samples 18/31 (58.1%) 31/77 (40.3%) n.s.
CSF TP, if elevated mg/dl 79 (46.7-176; 18) 62 (45.3-171.8; 31) 0.021
CSF TP, > 100 mg/dl Samples 6/30 (20%) 3/85 (3.5%) 0.009
CSF l-lactate, all mmol/l 2 (1.4-4.4; 22) 1.8 (1.1_4; 56) n.s.
CSF l-lactate, elevated Samples 9/22 (40.9%) 16/56 (28.6%) n.s.
CSF l-lactate, if elevated mmol/l 3.1 (2.3-4.4; 9) 2.6 (2.1-4; 16) 0.037
CSF l-lactate, > 3 mmol/l Samples 6/25 (24%) 4/60 (6.7%) n.s.
  1. Ratios and concentrations are given as median (with ranges and sample numbers in brackets)
  2. IgG-IF intrathecal IgG fraction; OCB oligoclonal bands; QAlb CSF/serum albumin quotient; TP total protein; WCC white cell count