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Table 8 CSF findings and attack severity

From: Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 1: Results from 163 lumbar punctures in 100 adult patients

 

Units

Severe attacks

Mild/moderate attacks

p value

WCC, all

Cells/μl

43.3 (0-410; 35)

7 (0-463;83)

0.0005

WCC, elevated

Samples

28/35 (80%)

44/83 (53%)

0.007

WCC, if elevated

Cells/μl

47 (6-410; 28)

24 (6-463;44)

n.s.

Neutrophils, all LPs

Samples

8/17 (47.1%)

18/40 (45%)

n.s.

OCB, pattern 2 or 3

Samples

5/32 (15.6%)

7/78 (9%)

n.s.

Link index

Samples

5/30 (16.7%)

4/68 (5.9%)

n.s.

QIgG, all

Ratio

4.2 (0.9-23.6; 30)

3.2 (1.1-14.1; 69)

0.012

QIgG, elevated

Samples

4/30 (13.3%)

5/69 (7.2%)

n.s.

QIgG, if elevated

Ratio

4.7 (2.3-6; 4)

4.5 (2.4-7; 5)

n.s.

QAlb, all

Ratio

7.9 (3.2-32.7; 30)

5.7 (3-26.3; 74)

0.009

QAlb, elevated

Samples

20/30 (66.7%)

29/74 (39.2%)

0.017

QAlb, if elevated

Ratio

10.8 (6.5-32.7; 20)

8.3 (5.5-26.3; 29)

0.014

CSF TP, all

mg/dl

55.1 (20.5-176; 31)

41.4 (20.4-171.8; 77)

0.026

CSF TP, elevated

Samples

18/31 (58.1%)

31/77 (40.3%)

n.s.

CSF TP, if elevated

mg/dl

79 (46.7-176; 18)

62 (45.3-171.8; 31)

0.021

CSF TP, > 100 mg/dl

Samples

6/30 (20%)

3/85 (3.5%)

0.009

CSF l-lactate, all

mmol/l

2 (1.4-4.4; 22)

1.8 (1.1_4; 56)

n.s.

CSF l-lactate, elevated

Samples

9/22 (40.9%)

16/56 (28.6%)

n.s.

CSF l-lactate, if elevated

mmol/l

3.1 (2.3-4.4; 9)

2.6 (2.1-4; 16)

0.037

CSF l-lactate, > 3 mmol/l

Samples

6/25 (24%)

4/60 (6.7%)

n.s.

  1. Ratios and concentrations are given as median (with ranges and sample numbers in brackets)
  2. IgG-IF intrathecal IgG fraction; OCB oligoclonal bands; QAlb CSF/serum albumin quotient; TP total protein; WCC white cell count