Table 3 Frequency of intrathecal IgM and IgA synthesis, IgM and IgA CSF/serum ratios, intrathecal IgM and IgA fractions, amount of locally produced IgM and IgA, and absolute IgM and IgA concentrations in the CSF and serum

 QIgM > Q_lim(IgM)

Samples

16/65 (25%)

16/57 (28%)

0/6 (0%)

9/18 (50%)

4/17 (24%)

3/22 (14%)

 QIgM, all LPs

–

0.4 (0–7.3; 63)

0.5 (0–7.3; 56)

0.2 (0.1–0.5; 5)

0.79 (0–6.72; 17)

0.35 (0–7.33; 16)

0.38 (0–4.17; 23)

 QIgM, if positive

–

1.7 (0.4–7.3; 16)

1.7 (0.4–7.3; 16)

n.a.

1.8 (0.45–6.72; 9)

0.76 (0.39–7.33; 4)

1.[74 (1.73–1.81; 3)

 IgM IF, all LPs

%IgM_CSF

0 (0–71.3; 62)

0 (0–71.3; 55)

0 (0–0;5)

0.2 (0–71.3; 17)

0 (0–51.3; 16)

0 (0–53.6; 22)

 IgM IF, QIgM pos

%IgM_CSF

26.3 (0.2–71.3; 16)

26.3 (0.2–71.3; 16)

n.a. (n.a.;0)

25.8 (0.2–71.3; 9)

17.5 (2.3–51.3; 4)

51 (26.8–53.6; 3)

 IgM IF, > 10%

Samples

13/62 (21%)

13/55 (23.6%)

0/5 (0%)

7/17 (41.2%)

3/16 (18.8%)

3/22 (13.6%)

 IgM Loc, all LPs

mg/l

0 (0–4.5;62)

0 (0–4.5; 55)

0 (0–0; 5)

0 (0–4.5; 17)

0 (0–3.5; 16)

0 (0–2.3; 22)

 IgM Loc, QIgM pos

mg/l

0.53 (0–4.47; 16)

0.53 (0–4.47; 16)

n.a.

0.6 (0–4.5; 9)

0.1 (0–3.5; 4)

1.3 (0.2–2.3; 3)

 IgM CSF

mg/l

0.43 (0–9.2; 67)

0.5 (0–9.2; 60)

0.41 (0.21–0.6; 5)

0.8 (0–9.2; 17)

0.3 (0–6.89; 16)

0.6 (0–4.2; 27)

 IgM serum

g/l

1.04 (0.35–2.6; 69)

1.03 (0.35–2.53; 62)

1.63 (0.9–2.6; 5)

1.09 (0.4–2.53; 20)

0.83 (0.52–1.34; 17)

1.18 (0.35–2.32; 25)

 QIgA > Q_lim(IgA)

Samples

18/65 (28%)

17/58 (29%)

1/5 (20%)

8/18 (44.4%)

2/17 (11.8%)

7/23 (30.4%)

 QIgA, all LPs

–

1.4 (0–16.1; 64)

1.4 (0–16.1; 57)

0.8 (0.6–1.6; 5)

2.62 (0–7.4; 17)

0.83 (0–8.52; 16)

1.39 (0–16.06; 24)

 QIgA, if positive

–

4.2 (1.3–16.1; 18)

5 (1.3–16.1; 17)

1.6 (1.6–1.6; 1)

5.08 (1.26–7.4; 8)

7.45 (6.38–8.52; 2)

3.06 (1.41–16.06; 7)

 IgA IF, all LPs

%IgA_CSF

0 (0–82.4; 63)

0 (0–82.4; 56)

0 (0–3.4; 5)

0 (0–48.9; 17)

0 (0–63.9; 16)

0 (0–82.4; 23)

 IgA IF, QIgA pos

%IgA_CSF

17.2 (1.1–82.4; 18)

19.5 (1.1–82.4; 17)

3.4 (3.4–3.4; 1)

13.7 (1.6–48.9; 8)

43.6 (23.3–63.9; 2)

36 (1.1–82.4; 7)

 IgA IF, > 10%

Samples

13/63 (20.6%)

13/56 (23.2%)

0/5 (0%)

6/17 (35.3%)

2/16 (12.5%)

5/23 (21.7%)

 IgA Loc, all LPs

mg/l

0 (0–6.5; 63)

0 (0–6.5; 56)

0 (0–0.1; 5)

0 (0–2.8; 17)

0 (0–3.3; 16)

0 (0–6.5; 23)

 IgA Loc, QIgA pos

mg/l

0.8 (0–6.5; 18)

1 (0–6.5; 17)

0.1 (0.1–0.1; 1)

0.8 (0.1–2.8; 8)

2.5 (1.7–3.3; 2)

0.6 (0–6.5; 7)

 IgA CSF

mg/l

1.6 (0–17.4; 66)

1.8 (0–17.4; 59)

0.98 (0.9–2.1; 5)

2.95 (0–17.4; 17)

0.9 (0–7.24; 16)

2.12 (0–10.4; 26)

 IgA serum

g/l

1.16 (0.05–6.6; 69)

1.16 (0.05–6.6; 62)

1.18 (0.94–2.7; 5)

1.22 (0.69–2.69; 20)

0.84 (0.3–2.61; 16)

1.21 (0.05–6.6; 26)