Table 3 Effects of PLX and LPS on gene expression of markers of microglia/macrophages and proinflammatory cytokines. F values (F(1, 20)) from 2 (PLX diet vs. control diet) × 2 (LPS vs. control) ANOVA with 6 mice/group
From: Microglia depletion fails to abrogate inflammation-induced sickness in mice and rats
Target molecule | PLX | LPS | PLX) × LPS |
|---|---|---|---|
Brain Cx3cr1 | F(1, 20) = 684*** | F(1, 20) = 5.29* | F(1, 20) = 6.53* |
Brain Itgam | F(1, 20) = 333*** | F(1, 20) = 9.61** | F(1, 20) = 7.56* |
Brain Il1b | F(1, 20) = 1.43 NS | F(1, 20) = 9.70** | F(1, 20) = 1.22 NS |
Brain Tnf | F(1, 20) = 0.75 NS | F(1, 20) = 21.1*** | F(1, 20) = 0.95 NS |
Brain Il6 | F(1, 20) = 0.30 NS | F(1, 20) = 7.56* | F(1, 20) = 4.55* |
Brain Il10 | F(1, 20) = 1.10 NS | F(1, 20) = 3.79+ | F(1, 20) = 4.88* |
Brain Oas1a | F(1, 20) = 0.29 NS | F(1, 20) = 14.7*** | F(1, 20) = 0.31 NS |
Liver Csf1r | F(1, 20) = 23.9*** | F(1, 20) = 12.3** | F(1, 20) = 4.95* |
Liver Itgam | F(1, 20) = 3.22 NS | F(1, 20) = 17.3*** | F(1, 20) = 2.42 NS |
Liver Il1b | F(1, 20) = 0.41 | F(1, 20) = 27.1*** | F(1, 20) = 0.34 |
Liver Tnf | F(1, 20) = 7.96** | F(1, 20) = 39.1*** | F(1, 20) = 7.86* |
Liver Il6 | F(1, 20) = 2.49 NS | F(1,20) = 23.6*** | F(1, 20) = 2.44 NS |
Liver Il10 | F(1,20) = 9.62** | F(1, 20) = 15.2*** | F(1, 20) = 9.18** |
Liver Oas1a | F(1, 20) = 4.15 NS | F(1, 20) = 28.9*** | F(1, 20) = 4.53* |