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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat

Fig. 8

Blockade of Nrf2 abolished the anti-Inflammation effect of DHLA. a Representative Western blot bands in the hippocampal region. b–f Statistical graphs of relative protein expression of Nrf2 (b), HO-1 (c), NLRP3 (d), caspase-1 (e), and IL-1β (f). g ROS expression in the hippocampal. The data were expressed as means ± SEM (n = 6). **P < 0.0001; ****P < 0.0001 versus the control group. ##P < 0.01; ###P < 0.001; ####P < 0.0001 versus the LPS group. &P < 0.05; &&P < 0.01 versus the LPS + DHLA group. The Shapiro-Wilk test results showed that all the data are normally distributed (p > 0.05)

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Journal of Neuroinflammation

ISSN: 1742-2094