Fig. 11

Schematic diagram illustrating the possible mechanisms of serum IgG-induced cytolysis of neurons. As we previously demonstrated, serum IgG from children with OMS and NB directly enhances the cytolysis of cultured cerebral cortical and cerebellar neurons. On the other hand, serum IgG also increases the activation of cultured microglias, leading to the upregulation of NO, which subsequently activate sGC and PKG in neurons, thereby inducing neuronal cytolysis. Although at the same time IGF-1/PI3K signaling may be activated to alleviate neuronal lysis, the impact of the NO/sGC/PKG pathway may be more predominant