Fig. 8
From: Orexin A alleviates neuroinflammation via OXR2/CaMKKβ/AMPK signaling pathway after ICH in mice
Western blot analysis evaluating the effects of OXR1 and OXR2. a Representative protein bands and the quantitative analysis of b ratio of p-CaMKKβ/CaMKKβ and c ratio of p-AMPK/AMPK at 24 h after ICH which was upregulated with OXA. The expressions of inflammatory factors d p-NFκB, e IL-1β, and f TNFα were significantly downregulated by OXA, which was consistent with the above results. Administration of SB-334867 (OXR1 antagonist) had no significant impact on the mice that received OXA, whereas JNJ-10397049 (OXR2 antagonist) significantly reversed the effects of OXA treatment. One-way ANOVA, *p < 0.05 vs. sham group, #p < 0.05 vs. vehicle group, @p < 0.05 vs. OXA group. Error bars represent mean ± SD, n = 6 per group