Fig. 9
From: Orexin A alleviates neuroinflammation via OXR2/CaMKKβ/AMPK signaling pathway after ICH in mice
ELISA tests to evaluate inflammation-related cytokines with OXA treatment. The levels of pro-inflammatory cytokines including a IL-1β, b TNFα, c IL-6, and d IL-12 were significantly downregulated with OXA treatment, and the levels of anti-inflammatory cytokines including e IL-4 and f IL-10 were significantly upregulated with OXA treatment evaluated at 24 h after ICH. The effects of OXA were reversed by CaMKKβ inhibitor (STO-609) and OXR2 inhibitor (JNJ-10397049) but not OXR1 inhibitor (SB-334867). One-way ANOVA, *p < 0.05 vs. sham group, #p < 0.05 vs. vehicle group, @p < 0.05 vs. OXA group. Error bars represent mean ± SD, n = 6 per group