Fig. 7
From: Rh-CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKCε pathway in a rat model of neonatal HIE
Effects of CSF1R inhibitor BLZ945 and PLCG2 inhibitor U73122 co-administration with rh-CSF1 on infarction volume, brain edema, body weight, geotaxis reflex at 48 h after HI. a-b All HI animals have a significantly greater percentage of infarction compare to the sham group. Rh-CSF1 treatment or Rh-CSF1 with DMSO significantly reduced the infarction area, but such effects were reversed by either BLZ945 or U73122. c Geotaxis reflex performance was significantly worse in all HI animals compared to the sham group. Rh-CSF1 treatment or Rh-CSF1 with DMSO treatment groups improved this neurological deficit. However, either BLZ945 or U73122 significantly abolished the neurological benefit of rh-CSF1 treatment. d All of HI animals had significant body weight loss than shams. Rh-CSF1 treatment or Rh-CSF1 with DMSO significantly attenuated HI-induced body weight loss, which were reversed by BLZ945 or U73122. e All HI animals showed significant brain water content increase compared with the sham group. Rh-CSF1 treatment or Rh-CSF1 with DMSO significantly reduced HI-induced brain edema, which were reversed by BLZ945 or U73122. *P < 0.05 vs. sham; #P < 0.05 vs. HI+ vehicle; @P < 0.05 vs. HI+ rh-CSF1+ DMSO. Data are represented as mean ± SD, n = 6 in each group