Fig. 2

Au treatment reduced brain edema and improved neurologic functions. a, b Effects of TBI and Au on water content (a) and neurologic deficits (b). c, d Representative western blot bands (c) and quantification of relative protein expression (d) for MMP-9. e Effects of Au on the latency to fall in the rotarod test were analyzed using two-way ANOVA. The Bonferroni post hoc test was used to compare differences among several groups at 14 days post-TBI. f Typical swimming path of mice in all groups during the training days (upper) and the probe trial period (lower) of the MWM test. i Effects of Au on the latency to find platform in the MWM test. The two-way ANOVA was performed, and the Bonferroni post hoc test was utilized to compare differences among several groups on day 28. j, k Au did not affect the average swimming speed during the training days (j) or during the probe trial period (k). l Time spent in the correct quadrant during the probe trail. m Number of crossings over the platform position during the probe trail. Bars represent the mean ± SD. *P < 0.05 versus indicated groups