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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Metformin inhibits intracranial aneurysm formation and progression by regulating vascular smooth muscle cell phenotype switching via the AMPK/ACC pathway

Fig. 7

VSMC proliferation, migration, and apoptosis are regulated via AMPK/ACC signaling. A Cell viability following treatment with ND-646 and ND-646 + metformin at indicated times. B Evaluation of VSMC migration with the transwell assay. Scale bar = 50 μM). (a–d) Representative images of control (a), (b) ND-646 (b), and ND-646 + 500 μM metformin (c) groups and quantitative analysis (d). C Apoptotic cells detected by Hoechst staining. Scale bar = 50 μM. (a–d) Representative images of control (a), (b) ND-646 (b), and ND-646 + 500 μM metformin (c) groups and quantitative analysis (d). *P < 0.05 vs control group. OD, optical density

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Journal of Neuroinflammation

ISSN: 1742-2094