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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Myeloproliferative blood cancers as a human neuroinflammation model for development of Alzheimer’s disease: evidences and perspectives

Fig. 2

Impact of early intervention with interferon-alpha2 (IFN) + JAK1/2 inhibitor ± statin upon the vicious self-perpetuating circle in MPNs. Early intervention with combination therapy is foreseen to prohibit disease progression by directly targeting the malignant clone (interferon) in concert with dampening of the inflammatory state (JAK1/2 inhibition, statin), which drives the malignant clone and also creates the soil for neuroinflammation and later development of Alzheimer’s disease. From this model, it is envisaged that treatment with IFN and JAK1/2 inhibitor may also be a highly important combination therapy for patients with early stage Alzheimer’s disease

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Journal of Neuroinflammation

ISSN: 1742-2094