Fig. 4

Mutations in blood cells give rise to chronic inflammation and elevated leukocyte and platelet counts, which together with endothelial cells are hyperactivated in MPNs. In polycythemia vera, red blood cell counts are elevated as well. Patients with MPNs and Alzheimer’s disease share several common pathways, which all together unite the different hypotheses of AD, the common denominators being chronic neuroinflammation and cerebral hypoperfusion, the latter being elicited by capillary stalling due to plugging of myeloid cells in the cerebral microcirculation