NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury

Table 1 Parameters of the Vehicle_M and MCC950 groups at baseline and during post-cardiac arrest care after ROSC

Parameters	Time points	Vehicle_M	MCC950
Body weight, g	Baseline	377 ± 18	384 ± 20
Time from asphyxia to cardiac arrest, s	Baseline	214.0 ± 21	210.9 ± 17
Time required for ROSC, s	Baseline	90.77 ± 24	93.78 ± 27
Total dose of epinephrine, μg	Baseline	13.2 ± 3.1	12.0 ± 3.4
Mean arterial pressure, mmHg	Baseline	122 ± 8	120 ± 11
	10 min	113 ± 7	110 ± 9
	30 min	88 ± 10	91 ± 7
	60 min	85 ± 7	81 ± 9
Heart rate, beats/min	Baseline	400 ± 11	399 ± 9
	10 min	419 ± 17	424 ± 20
	30 min	364 ± 17	370 ± 16
	60 min	375 ± 14	380 ± 9
Rectal temperature, °C	Baseline	37.1 ± 0.3	37.0 ± 0.2
	10 min	37.1 ± 0.2	36.8 ± 0.3
	30 min	37.0 ± 0.3	36.9 ± 0.2
	60 min	37.0 ± 0.2	36.9 ± 0.3

Physiological variables are measured at baseline and at 10, 30, and 60 min after ROSC. The values are expressed as mean ± SD. Vehicle_M vehicle of MCC950

ISSN: 1742-2094