NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury

Table 2 Parameters of the of the Vehicle_A and Ac-YVAD-cmk groups at baseline and during post-cardiac arrest care after ROSC

Parameters	Time points	Vehicle_A	Ac-YVAD-cmk
Body weight, g	Baseline	381 ± 13	374 ± 17
Time from asphyxia to cardiac arrest, s	Baseline	220.4 ± 15	217.1 ± 23
Time required for ROSC, s	Baseline	99.06 ± 17	96.45 ± 22
Total dose of epinephrine, μg	Baseline	12.3 ± 3.1	11.1 ± 3.0
Mean arterial pressure, mmHg	Baseline	119 ± 7	124 ± 11
	10 min	116 ± 12	107 ± 7
	30 min	84 ± 9	83 ± 5
	60 min	80 ± 5	81 ± 11
Heart rate, beats/min	Baseline	407 ± 11	403 ± 7
	10 min	431 ± 15	427 ± 19
	30 min	372 ± 11	369 ± 17
	60 min	383 ± 17	379 ± 15
Rectal temperature, °C	Baseline	36.8 ± 0.4	36.9 ± 0.2
	10 min	37.1 ± 0.3	36.9 ± 0.3
	30 min	37.0 ± 0.2	36.8 ± 0.3
	60 min	36.8 ± 0.2	36.9 ± 0.2

Physiological variables are measured at baseline and at 10, 30, and 60 min after ROSC. The values are expressed as mean ± SD. Vehicle_A vehicle of Ac-YVAD-cmk

ISSN: 1742-2094