Fig. 4

Outcome parameter in comparison of P301S and wild-type mice. a Longitudinal accumulation of tau measured via AT8 immunohistochemistry and representative images of co-staining with IBA1 and CD68 in the cortex (upper row) and brainstem (lower row). n (2.7 M/4.8 M) = 3; n (6.6 M) = 14. Scale bar = 30 μm. b Performance of mice in Morris water maze (MWM) at study termination with escape latency, velocity, swimming distance, and frequency of platform crossing. n = 22 P301S, n = 18 WT. c Glucose metabolism (FDG-PET uptake) in the different target VOIs at 6.4 months of age and SPM results of the contrast P301S and wild-type (WT) mice. n = 24 P301S, n = 16 WT. Color coding shows regions with decreased glucose metabolism (T-scores) in P301S mice when compared to WT upon an MRI template in sagittal and coronal slices, as indicated by red lines in the axial MRI slice. CTX, cortex; HIP, hippocampus; BRST, brainstem; CBL, cerebellum; M, months; SUVR, standardized uptake value ratio; *p < 0.05; **p < 0.01; ***p < 0.001. All error bars indicate SD