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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Inhibition of leucine-rich repeats and calponin homology domain containing 1 accelerates microglia-mediated neuroinflammation in a rat traumatic spinal cord injury model

Fig. 6

LRCH1 knockdown enhances microglia-mediated neuroinflammation after SCI. a, b Representative dot plots showing the gating of αβT cells, GFP+ exogenous microglia (on day 6 after SCI), as well as γδT cells and neutrophils (on day 2 after SCI) in isolated spinal cord cells. LC, rats receiving microglia infected with control lentivirus. LL, rats receiving microglia infected with LRCH1 shRNA-encoding lentivirus. c, d Statistics for the frequencies of GFP+ microglia (c) and indicated leukocyte populations (d) in spinal cord cells. e mRNA levels of indicated cytokines in GFP+ microglia sorted from recipient spinal cords. n = 5 in 3 independent experiments. ns, non-significant. *p < 0.05; **p < 0.01; ***p < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094