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Table 1 Summary of microglial morphometric parameters of sham and HF rats for the PVN and CeA

From: Three-dimensional morphometric analysis reveals time-dependent structural changes in microglia and astrocytes in the central amygdala and hypothalamic paraventricular nucleus of heart failure rats

Brain region Group Cell
volume
(μm3)
Surface
area
(μm2)
Filament
length
(μm)
Microglial
branches
Microglial
segments
Filament
terminals
IBA1
intensity
(AU)
PVN Sham 8 weeks
N = 381 cells
n = 4 animals
3157 ± 112 4048 ± 99 745 ± 21 104 ± 3 219 ± 7 116 ± 4 9449 ± 123
Sham 14 weeks
N = 365 cells
n = 4 animals
3098 ± 119 4100 ± 107 736 ± 18 102± 4 224 ± 8 118 ± 6 9385 ± 135
Sham 16 weeks
N = 389 cells
n = 4 animals
3181 ± 122 4068 ± 81 761 ± 25 100 ± 5 216 ± 7 117 ± 6 9522 ± 139
HF 8 weeks
N = 378 cells
n = 4 animals
2838 ± 58 3868 ± 75 642 ± 12 82 ± 2 171 ± 5 90 ± 3 11138 ± 118
HF 14 weeks
N = 407 cells
n = 4 animals
2212 ± 74 3424 ± 64 629 ± 35 78 ± 2 163 ± 7 85 ± 3 12764 ± 202
HF 16 weeks
N = 399 cells
n = 4 animals
2012 ± 69 3233 ± 59 524 ± 39 72 ± 3 150 ± 5 83 ± 4 12783 ± 231
HF 16 weeks EF > 50%
N = 435 cells
n = 5 animals
3234 ± 128 3988 ± 90 741 ± 27 97 ± 6 216 ± 8 115 ± 9 9433 ± 146
CeA Sham 8 weeks
N = 377 cells
n = 4 animals
3588 ± 137 4885 ± 119 841 ± 28 109 ± 6 219 ± 7 114 ± 3 10134 ± 137
Sham 14 weeks
N = 339 cells
n = 4 animals
3644 ± 122 4966 ± 131 865 ± 31 102 ± 2 214 ± 5 116 ± 4 10073 ± 144
Sham 16 weeks
N = 354 cells
n = 4 animals
3691 ± 123 4904 ± 127 833 ± 24 104 ± 5 216 ± 7 114 ± 3 10285 ± 180
HF 8 weeks
N = 363 cells
n = 4 animals
3634 ± 119 4700 ± 124 765 ± 29 106 ± 4 222 ± 7 112 ± 3 10344 ± 176
HF 14 weeks
N = 355 cells
n = 4 animals
4418 ± 187 4964 ± 144 781 ± 28 92 ± 4 192 ± 8 100 ± 3 11314 ± 277
HF 16 weeks
N = 332 cells
n = 4 animals
3180 ± 115 4395 ± 163 623 ± 24 89 ± 3 179 ± 6 94 ± 4 12779 ± 357
HF 16 weeks EF > 50%
N = 384 cells
n = 5 animals
3540 ± 132 4798 ± 141 835 ± 56 94 ± 4 202 ± 7 110 ± 4 11322 ± 290
S1BF Sham 14 weeks
N = 139 cells
n = 4 animals
4577 ± 138 6008 ± 234 967 ± 31 125 ± 5 261 ± 8 135 ± 7 10539 ± 183
HF 14 weeks
N = 162 cells
n = 4 animals
4257 ± 130 5664 ± 224 957 ± 31 126 ± 4 264 ± 8 138 ± 8 10647 ± 171
  1. Table shows individual values (mean ± SEM) of all analyzed microglial parameters, N = number of analyzed microglia, n = number of animals per group, CeA = central amygdala, PVN = paraventricular nucleus, S1BF = somatosensory cortex barrel field 1