Table 2 Genes differentially regulated in males and females in the GABA/glutamate and dopamine/serotonin neurotransmission systems
From: A pivotal role for Interferon-α receptor-1 in neuronal injury induced by HIV-1
GABAergic & glutamatergic neurotransmission systems (male) | ||||||||
HIVgp120 | IFNAR1KO | IFNAR1KO gp120 | ||||||
Gene | Fold regulation | Pvalue | Gene | Fold regulation | Pvalue | Gene | Fold Regulation | Pvalue |
Gabrr1 | 4.00 | 0.041 | Gabrb1 | 1.16 | 0.003 | Cdk5r1 | −1.21 | 0.020 |
P2rx7 | 1.46 | 0.002 | Gabra5 | −1.32 | 0.040 | |||
Slc1a2 | −1.17 | 0.044 | Gabrb1 | 1.13 | 0.046 | |||
Slc1a3 | 1.21 | 0.003 | Gabrb3 | −1.14 | 0.035 | |||
Slc6a1 | −1.21 | 0.023 | Gabrr1 | 13.52 | 0.006 | |||
Slc7a11 | 2.52 | 0.000 | Gls | −1.15 | 0.027 | |||
B2m | 1.90 | 0.017 | Grin1 | −1.29 | 0.027 | |||
Grin2b | −1.35 | 0.036 | ||||||
Grin2c | −1.91 | 0.041 | ||||||
Grm5 | −1.21 | 0.026 | ||||||
Mapk1 | −1.24 | 0.026 | ||||||
Slc1a3 | 1.15 | 0.033 | ||||||
Slc6a1 | −1.18 | 0.045 | ||||||
Slc6a12 | 3.50 | 0.024 | ||||||
Slc7a11 | 2.77 | 0.000 | ||||||
GABAergic & glutamatergic neurotransmission systems (female) | ||||||||
HIVgp120 | IFNAR1KO | IFNAR1KO gp120 | ||||||
Gene | Fold regulation | Pvalue | Gene | Fold regulation | Pvalue | Gene | Fold regulation | Pvalue |
Cdk5r1 | −1.25 | 0.047 | Aldh5a1 | −1.30 | 0.039 | Cacna1a | −1.60 | 0.011 |
Gabbr2 | −1.36 | 0.031 | Gabbr2 | −1.74 | 0.005 | Gnai1 | −1.26 | 0.010 |
Glul | −1.39 | 0.014 | Grik1 | 1.36 | 0.040 | Grin2c | −1.77 | 0.029 |
Gnai1 | −1.27 | 0.046 | Grm1 | −1.47 | 0.030 | Pla2g6 | 1.16 | 0.015 |
Gnaq | −1.18 | 0.005 | Grm3 | 1.21 | 0.015 | Slc7a11 | 1.85 | 0.044 |
Gphn | −1.38 | 0.025 | Itpr1 | 1.16 | 0.043 | |||
Grik4 | −1.66 | 0.048 | ||||||
Grin2c | −1.71 | 0.030 | ||||||
Grm7 | −1.25 | 0.021 | ||||||
Grm8 | −1.36 | 0.032 | ||||||
Slc6a1 | −1.33 | 0.023 | ||||||
Slc6a12 | −2.50 | 0.039 | ||||||
Slc6a13 | −2.11 | 0.017 | ||||||
Slc7a11 | 1.84 | 0.002 | ||||||
B2m | 1.73 | 0.024 | ||||||
Dopaminergic & serotonergic neurotransmission systems (male) | ||||||||
HIVgp120 | IFNAR1KO | IFNAR1KO gp120 | ||||||
Gene | Fold regulation | Pvalue | Gene | Fold regulation | Pvalue | Gene | Fold regulation | Pvalue |
Adcy5 | −1.27 | 0.018 | Htr2c | −1.27 | 0.0449 | Adcy5 | −1.42 | 0.002 |
Adrbk1 | −1.21 | 0.045 | Htr4 | −1.17 | 0.0391 | Adrb2 | 1.39 | 0.009 |
Akt1 | −1.14 | 0.014 | Adrbk1 | −1.14 | 0.008 | |||
Gfap | 14.54 | 0.000 | Akt1 | −1.30 | 0.001 | |||
Grk6 | −1.15 | 0.036 | Cacna1a | −1.63 | 0.022 | |||
Gsk3a | −1.18 | 0.023 | Ephb1 | 1.77 | 0.004 | |||
Gsk3b | −1.18 | 0.029 | Fos | 1.90 | 0.014 | |||
Htr2c | −1.29 | 0.023 | Gfap | 13.82 | 0.000 | |||
Htr3a | −1.21 | 0.027 | Grk6 | −1.46 | 0.003 | |||
Htr5a | −1.55 | 0.032 | Gsk3a | −1.27 | 0.006 | |||
Snca | −1.25 | 0.037 | Htr1a | −1.65 | 0.024 | |||
Syn2 | −1.20 | 0.047 | Htr4 | −1.49 | 0.008 | |||
Mapk1 | −1.27 | 0.046 | ||||||
Syn2 | −1.34 | 0.018 | ||||||
Dopaminergic & serotonergic neurotransmission systems (female) | ||||||||
HIVgp120 | IFNAR1KO | IFNAR1KO gp120 | ||||||
Gene | Fold regulation | Pvalue | Gene | Fold regulation | Pvalue | Gene | Fold regulation | Pvalue |
Adcy5 | −1.45 | 0.020 | Arrb1 | −1.59 | 0.018 | Arrb1 | −1.32 | 0.033 |
Adrbk2 | −1.26 | 0.010 | Drd1 | 1.56 | 0.046 | Casp3 | 1.23 | 0.024 |
Arrb1 | −1.43 | 0.014 | Grk4 | 1.45 | 0.046 | Cyp2d22 | 1.34 | 0.050 |
Gfap | 10.43 | 0.001 | Pik3ca | −1.37 | 0.045 | Gfap | 12.41 | 0.000 |
Gsk3b | −1.26 | 0.016 | Ppp1r1b | 1.51 | 0.048 | Gsk3b | −1.19 | 0.036 |
Itpr1 | −1.13 | 0.040 | Pla2g5 | 4.07 | 0.025 | |||
Tph1 | −2.24 | 0.047 | Plcb3 | 1.31 | 0.033 | |||
B2m | 1.89 | 0.012 | ||||||