Fig. 6
From: Thrombomodulin facilitates peripheral nerve regeneration through regulating M1/M2 switching
TM enhanced M2 polarization in a proinflammatory microenvironment. a Immunohistochemical staining of transverse nerve sections from Sprague-Dawley rats. S100 and PGP9.5 staining of a transverse nerve section demonstrated a higher proportion of Schwann cells and axons in TM-treated nerves. TM treatment also reduced the number of GFAP+ cells at the site of injury. n = 5. b Immunolabeling of CD68, CD86, and CD206 in nerve sections from the TM and PBS groups. Scale bar, 20 μm. n = 5. Mean ± SD. *p < 0.05 compared with the PBS group