Fig. 1

Purported neurotoxic, neuroprotective, and pan-reactive astrocyte transcriptomic signatures in acute injury and chronic neurodegenerative mouse models. Heatmaps illustrate the log₂(fold-change) (a) and − log₁₀(p values) (b) of the neurotoxic (A1), neuroprotective (A2), and pan-reactive (PAN) gene cassettes as defined by Liddelow et al. [2]. Dark gray in (a) and (b) means that the transcript was not detected or was detected at extremely low levels. Light gray transcripts in (b) were not statistically significant. Note that all three signatures are significantly upregulated in astrocytes from chronic neurodegeneration (ND) and, specially, acute injury (AI) mouse models