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Table 2 Inflammation levels after CPAP treatment in OSAS patients

From: The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome

Reference Number of patients Treatment duration Daily duration Detecting parameter Before treatment After treatment
Schiza et al. 2010 [60] 528 12 months ≥ 4 h/night CRP CRP↑ CRP↓
Steiropoulos et al. 2009 [61] 52 6 months ≥ 4 h/night TNF-α, IL-6, UA and CD4+ cell count TNF-α↑ UA↑
CD4+ cell count↑
TNF-α↓
UA↓
CD4+ cell count↓
Yokoe et al. 2003 [62] 30 1 month NA CRP, IL-6 CRP↑
IL-6↑
CRP↓
IL-6↓
Jin et al. 2017 [63] 100 3 months NA IL-8, TNF-α, CRP, ICAM-1, VCAM-1, and selectin IL-8↑
TNF-α↑
CRP↑
ICAM-1↑
VCAM-1↑
selectin↑
IL-8↓
TNF-α↓
CRP↓↓
ICAM-1↓
VCAM-1↓
selectin↓
Wu et al. 2010 [64] 30 2 months NA HMGB1 and NOx HMGB1↑
NOx ↓
HMGB1↓
NOx↑
Kuramoto et al. 2009 [65] 116 3 months NA SAA, CRP CRP↑
SSA↑
SAA↓
Ohga et al. 2003 [66] 20 8–18 months NA ICAM-1, IL-8, MCP-1 ICAN-1↑
IL-8↑
MCP-1↑
ICAM-1↓
IL-8↓
Lu et al. 2017 [67] 58 2 months NA NF-κB, HIF-1α and SPD NF-κB↑
HIF-1α↑
SPD↓
SPD↑
NF-κB↓
HIF-1α↓
Tichanon et al. 2016 [68] 13 3 months ≥ 5 h/night FeNO, MDA FeNO↑
MDA↑
FeNO↓
MDA↓
  1. CRP C-reactive protein, TNF-α tumor necrosis factor-α, IL interleukin, ICAM-1 intercellular adhesion molecules-1, VCAM-1 vascular cell adhesion molecule-1, UA uric acid, NF-κB nuclear factor kappa B, HMGB1 high mobility group box 1, NOx nitric oxide derivative, SSA serum amyloid A, MCP-1 monocyte chemoattractant protein-1, HIF- hypoxia-inducible factor-1α, SPD surfactant protein D, FeNO fractional exhaled nitric oxide, MDA malondialdehyde, NA not administrated