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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Chitotriosidase, a biomarker of amyotrophic lateral sclerosis, accentuates neurodegeneration in spinal motor neurons through neuroinflammation

Fig. 7

Hypothesis of mechanisms of CHIT-1 induced neurotoxicity in ALS. CHIT-1 activates microglial cells by possibly interacting with receptors (e.g. transforming growth factor beta (TGF-β) or toll-like receptors) leading to the release of proinflammatory mediators. This leads to the heightened glial response with an increase in reactive astrocytes and activated microglia. Neurotoxic cytokines like IL-6, TNF-α along with ROS and nitric oxide released by both these glial cell types result in motor neuronal degeneration

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Journal of Neuroinflammation

ISSN: 1742-2094