Table 3 mHFD effects on microglial density, distribution, and peripheral myeloid cell infiltration in the dorsal hippocampus CA1 of PND30 offspring
Parameters | Mean ± standard error of the mean | F | p | ||||
|---|---|---|---|---|---|---|---|
Male | Female | ||||||
CD | mHFD | CD | mHFD | ||||
St rad | Density (cells/mm2) | 228.5 ± 12.1 | 233.8 ± 2.1 | 225.4 ± 10.1 | 214.9 ± 5.4 | Sex × diet, 0.8838 Sex, 1.725 Diet, 0.09162 | Sex × diet, 0.3611 Sex, 0.2075 Diet, 0.7660 |
Spacing Index (a.u.) | 0.452 ± 0.014 | 0.469 ± 0.006 | 0.456 ± 0.011 | 0.454 ± 0.013 | Sex × diet, 0.6857 Sex, 0.2303 Diet, 0.4325 | Sex × diet, 0.4198 Sex, 0.6378 Diet, 0.5201 | |
Cluster | 0.261 ± 0.138 | 0.051 ± 0.031 | 0.182 ± 0.084 | 0.222 ± 0.091 | Sex × diet, 1.759 Sex, 0.2359 Diet, 0.8177 | Sex × diet, 0.2034 Sex, 0.6338 Diet, 0.3793 | |
%Infiltration | 0.201 ± 0.131 | 0.150 ± 0.092 | 0.270 ± 0.143 | 0.000 ± 0.000 | Sex × diet, 1.031 Sex, 0.1433 Diet, 2.241 | Sex × diet, 0.3250 Sex, 0.7100 Diet, 0. 1539 | |
St lac mol | Density (cells/mm2) | 248.8 ± 14.5 | 272.7 ± 14.2 | 239.4 ± 11.8 | 259.6 ± 15.0 | Sex × diet, 0.01730 Sex, 0.6481 Diet, 2.507 | Sex × diet, 0.8970 Sex, 0.4326 Diet, 0.1329 |
Spacing Index (a.u.) | 0.473 ± 0.019 | 0.466 ± 0.004 | 0.442 ± 0.016 | 0.470 ± 0.022 | Sex × diet, 1.105 Sex, 0.6448 Diet, 0.4185 | Sex × diet, 0.3089 Sex, 0.4337 Diet, 0.5268 | |
Cluster | 0.122 ± 0.062 | 0.179 ± 0.093 | 0.029 ± 0.029 | 0.147 ± 0.065 | Sex × diet, 0.2179 Sex, 0.9011 Diet, 1.739 | Sex × diet, 0.6469 Sex, 0.3566 Diet, 0.2058 | |
%Infiltration | 0.073 ± 0.073 | 0.437 ± 0.151 | 0.233 ± 0.154 | 0.216 ± 0.091 | Sex × diet, 2.421 Sex, 0.06043 Diet, 2.006 | Sex × diet, 0.1393 Sex, 0.8089 Diet, 0.1758 | |