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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Ingestion of Lactobacillus intestinalis and Lactobacillus reuteri causes depression- and anhedonia-like phenotypes in antibiotic-treated mice via the vagus nerve

Fig. 4

Effects of L. intestinalis and L. reuteri in the antibiotic-treated mice. a Body weight (repeated measure two-way ANOVA, antibiotic: F1,27 = 9.281, P = 0.005; transplantation: F1,27 = 1.284, P = 0.267). b Locomotion (LMT) (one-way ANOVA, F2,27 = 0.533, P = 0.593). c TST (one-way ANOVA, F2,27 = 9.695, P = 0.001). d FST (one-way ANOVA, F2,27 = 10.749, P < 0.001). e SPT (one-way ANOVA, F2,27 = 8.214, P = 0.002). f Plasma IL-6 (one-way ANOVA, F2,27 = 2.775, P = 0.080). g GluA1 (one-way ANOVA, F2,27 = 15.481, P < 0.001). h PSD-95 (one-way ANOVA, F2,27 = 9.185, P = 0.001). Data are shown as mean ± S.E.M. (n = 10). *P < 0.05, **P < 0.01, ***P < 0.001. NS not significant, W + W water + water-treated mice, A + W antibiotic + water-treated mice, A + M antibiotic + microbiota transplantation

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