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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling

Fig. 7

Knockdown of miR-195 directly in BV2 cells induced microglial polarized toward M1 phenotype dependent on the CX3CR1 expression. a The effects of miR-195 on endogenous CX3CR1 expression in BV2 cells by immunofluorescence staining and western blotting after the BV2 cells were transfected with miR-195, AMO-195, miR-195 + AMO-195, miR-195 + Cx3cr1-ODN, or NC. b Downregulating miR-195 directly in the BV2 cells increased the ratio of CD68/CD206 in Iba-1+ cells. Bars represent the mean ± SD, n = 3 batches of cell culture. *P < 0.05 vs NC; #P < 0.05 vs miR-195. Scale bar: 40 μm. All data were analyzed using one-way ANOVA followed by Tukey test

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Journal of Neuroinflammation

ISSN: 1742-2094