Table 1 The differential Alzheimer’s disease gene expression profiles in WT and APP/PS1 mice after BaP exposure

Inflammatory and immunoregulatory process

Interleukin 1 alpha (Il1a)

1.00

0.97

0.90

1.92^*#

Interleukin 1 beta (IL1β)

1.00

0.65^**

4.01^**

4.67^**#

Interleukin 3 (IL3)

1.00

3.75^*

2.82^*

3.81^*

Interleukin 6 (Il6)

1.00

0.94

1.30

2.14^*#

gp91

1.00

3.19^*

4.88^*

5.71^*

p67

1.00

1.51

2.75^*

2.76^*

p47

1.00

0.99

1.42

1.36

p40

1.00

1.17

1.97^*

1.77^*

iNOS

1.00

0.58^*

0.75

1.41^*#

CD36 antigen (Cd36)

1.00

2.65^**

2.58^**

7.41^**#

Chemokine ligand 5 (Ccl5)

1.00

1.03

4.19^*

2.91^**#

Chemokine ligand 7 (Ccl7)

1.00

1.25

2.14^*

1.56^*

Tumor necrosis factor (Tnf)

1.00

1.70^*

2.61^**

10.19^**#

Arginase (Arg1)

1.00

0.94

1.40

5.61^*#

TREM2

1.00

1.06

1.67^*

5.86^*#

Prostaglandin-endoperoxide synthase 2 (Ptgs2)

1.00

1.60^*

0.92

2.89^*

Secretases

Amyloid beta precursor protein (APP)

1.00

2.51^*

6.56^*

8.15^*#

Beta-site APP cleaving enzyme 1 (Bace1)

1.00

1.24^*

2.10^*

2.93^*#

Presenilin 1 (Psen1)

1.00

0.97

2.07^*

2.93^**#

Presenilin 2 (Psen2)

1.00

0.93

1.27

1.88^*#

Nicastrin (Ncstn)

1.00

1.04

2.61^**

3.24^**#

Anterior pharynx defective 1b homolog (Aph1b)

1.00

1.44^*

2.78^**

3.20^*#

Presenilin enhancer 2 (Pen2)

1.00

1.15

1.11

1.15

Beta-amyloid degradation

Membrane metallo endopeptidase

1.00

1.77^*

1.32

4.75^*#

Plasminogen activator (Plau)

1.00

1.05

3.13^*

3.97^*#

Insulin degrading enzyme (IDE)

1.00

1.04

2.53^**

3.16^*#

Neprilysin (NEP)

1.00

2.53^*

0.29^*

0.52^*#

Synaptic formation

Zinc transporter (Slc30a3)

1.00

1.75^**

0.86

2.81^*

Aplipoprotein E (Apoe)

1.00

2.17^*

0.85^*

1.49^*

Brain-derived neurotrophic factor (Bdnf)

1.00

1.43^**

3.34^**

3.65^**#

Nerve growth factor receptor (Ngfr)

1.00

1.59^*

2.64^*

5.49^**#

Neurotransmitter transporter (Slc6a4)

1.00

0.84

0.25^*

0.48^**

Agrin (Agrn)

1.00

1.32

1.39

0.48^*#

Glial cell line-derived neurotrophic factor (Gdnf)

1.00

1.26

1.32^*

2.74^*

Acetylcholinesterase (Ache)

1.00

1.33^*

9.31^*

5.14^*#