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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation

Fig. 1

Levels of cytokines and NLRP3 inflammasome components in the brain after CA/CPR. Mice were subjected to sham or CA/CPR surgery. Brain cortical samples were collected on day 1 or day 3 after CA/CPR. a Cytokines in the post-CA brain. The mRNA levels of tumor necrosis factor alpha (TNF-α), interleukin 1beta (IL-1β), and transforming growth factor beta (TGF-β), were measured by qRT-PCR. b, c NLRP3 inflammasome components in the post-CA brain. b The protein levels of NLRP3 and ASC were evaluated by Western blotting. β-actin was used as a loading control. c The mRNA levels of NLRP3 and IL-18 in the brain on day 3 after CA/CPR. The mean values in sham samples were set to 1.0. Data are presented as mean ± SEM (n = 4/group). *p < 0.05; **p < 0.01; ***p < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094