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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Mice defective in interferon signaling help distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease

Fig. 5

Primary and secondary pathological pathways in nGD. Upon GlcCer/GlcSph accumulation, changes occur in a number of pathways related to altered SL, lipid or lysosomal function, which results in concomitant changes in a number of downstream pathways (green), which are classified as primary pathological pathways. IFN-associated pathways (red) can be eliminated without effect on mice lifespan, suggesting that they are secondary pathways. For further details, see text

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Journal of Neuroinflammation

ISSN: 1742-2094