Fig. 5
![Fig. 5](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12974-020-01934-x/MediaObjects/12974_2020_1934_Fig5_HTML.png)
Primary and secondary pathological pathways in nGD. Upon GlcCer/GlcSph accumulation, changes occur in a number of pathways related to altered SL, lipid or lysosomal function, which results in concomitant changes in a number of downstream pathways (green), which are classified as primary pathological pathways. IFN-associated pathways (red) can be eliminated without effect on mice lifespan, suggesting that they are secondary pathways. For further details, see text