Fig. 1

Survival analysis of mice infected with the indicated TBEV strains. Six- to 10-week-old C57BL/6 mice were infected intraperitoneally with 10⁴ FFU of TBEV strains. a European subtypes (HM467/09, Neudörfl, and AS33, N = 5, 93/783, Torö, and Hypr N = 10). Statistical significance between 93/783 and the other TBEV strain were calculated using log-rank (Mantel-Cox) test (***Torö, ***Hypr, **Neudörfl, ***AS33, **HM467/11). b Siberian and Far Eastern subtypes (Sofjin, Aina, and M14/10 N = 5, Torö, and 93/783 N = 10) compared to 93/783 and Torö. Statistical significance between 93/783 and the other TBEV strain were calculated using log-rank (Mantel-Cox) test (**Aina, **M14/10, ***Sofjin). c Six- to 10-week-old C57BL/6 mice were infected intracranially with 10² FFU of 93/783 or Torö (N = 10). Asterisks indicate statistical significance vs 93/783 calculated using log-rank (Mantel-Cox) test (**P < 0.01 ***P < 0.001)