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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Splenic sympathetic signaling contributes to acute neutrophil infiltration of the injured spinal cord

Fig. 4

Less neutrophils in the spleen of denervated (Dxn) animals 24 hpi. a Schematic representation of the sympathetic signaling interruption by splenic denervation. Created with BioRender.com. b Experimental setup. c Flow cytometry plots demonstrating monocytes (CD11b+Ly6G-Ly6C+) and neutrophil (CD11b+Ly6G+Ly6C+) populations present in the spleen 24 hpi in SCI vs Dxn + SCI animals. d–f Frequency of myeloid (CD11b+) cells, monocytes (CD11b+Ly6G-Ly6C+), and neutrophils (CD11b+Ly6G+Ly6C+) present at the spleen 24 hpi in SCI and Dxn + SCI animals. f Concentration of neutrophils in the spleen 24 hpi in SCI vs Dxn + SCI animals. N (SCI) = 4; n (Dxn + SCI) = 6. Statistical tests: d–g unpaired t test. Results expressed as mean ± SEM. **p < 0.01

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Journal of Neuroinflammation

ISSN: 1742-2094