Fig. 3

LGTV infection affected exploratory behavior in the open field test. Uninfected control (WT: n = 10, Irf-7^−/−: n = 8) and LGTV-infected (10⁴ FFU, i.p.) mice (WT: n = 10, Irf-7^−/−: n = 9) were tested for 5 min in the open field arena 14 days post-infection. a Total distance traveled, b average speed, c activity percentage of mice in the border (B) and central (C) zones of the open field arena, and d the number of core entries are presented. e Group mean heat map of the animals’ center position are illustrated for all tested groups. One-way ANOVA and post hoc Student’s t test using Fisher’s least significant differences were employed to analyze the data. Data are shown as mean ± SEM, *p < 0.05, **p < 0.01, and ***p < 0.001