Fig. 5

LGTV infection led to cognitive impairment in wildtype mice. Uninfected control (WT: n = 9, Irf-7^−/−: n = 7) and LGTV-infected (10⁴ FFU, i.p.) mice (WT: n = 10, Irf-7^−/−: n = 9) were trained in the Morris water maze test for 8 consecutive days. a, b Escape latency and c–f swim distance of control and infected wildtype and Irf-7^−/− mice are shown. Two-way ANOVA with one repeated measure and post hoc Student’s t test using Fisher’s least significant differences were employed to analyze the data. Data are shown as mean ± SEM, *p < 0.05, **p < 0.01, and ***p < 0.001