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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Langat virus infection affects hippocampal neuron morphology and function in mice without disease signs

Fig. 8

LGTV infection impaired memory formation for a new platform position in wildtype mice. Uninfected control (WT: n = 9, Irf-7−/−: n = 7) and LGTV-infected (104 FFU, i.p.) mice (WT: n = 10, Irf-7−/−: n = 9) were trained for another 3 consecutive days of reversal training in the Morris water maze following initial acquisition. a, b The escape latency and swim distance to reach a new position of the hidden platform (SW) in wildtype and c, d Irf-7−/− mice are presented. e A single probe trial test 24 h after the last day of reversal training was shown. The percentage of time spent in the target quadrant (T, south west) in comparison with the average time spent in non-target quadrants (N) by control and LGTV infected wildtype and Irf-7−/− mice are shown. f Group mean heat map of the animals’ center position for all tested groups are illustrated. Two-way ANOVA with one repeated measure and post hoc Student’s t test using Fisher’s least significant differences was employed to analyze the data. Data are shown as mean ± SEM, *p < 0.05 and **p < 0.01

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