Fig. 1

Altered DICER expression in human MG thymuses. a RT-PCR analysis for DICER mRNA in the thymus of non-MG adults (n = 6) and MG patients (n = 12) with a low (orange dots) and high (red dots) degree of thymic hyperplasia. Data were normalized to the 28S. P values were assessed by the Mann-Whitney test. b Correlation between DICER and CD19 mRNA expression in control (grey dots) and MG thymuses (orange and red dots) was performed using Spearman’s correlation test, with a p < 0.05 considered significant. c Using data from a thymic miRnome study [10], the distribution of FCs (fold changes) for 1733 mature miRNAs. Each FC was calculated by comparing the mean of raw intensity values for MG thymuses (n = 12) over the one of non-MG adult control thymuses (n = 6). d Correlation between DICER mRNA and miR-29a-3p expression in control (grey dots) and MG thymuses (orange and red dots) was performed using Spearman's correlation test, with a p < 0.05 considered significant