Fig. 3

Time activity curve (TAC) of [¹¹C]SMW139 uptake in the spinal cord, cerebellum, and brain stem (%ID/mL) at the peak of the EAE disease (red circle) and at the recovery phase (blue square). TAC of [¹¹C]SMW139 in the severe-relapsing (a–c), severe acute (d–f), and mild acute (g–i) EAE animals and CFA control animals (j–l). Quantification of PET imaging in the spinal cord, cerebellum, and brain stem of a single-frame static reconstruction between 5 and 45 min post [¹¹C]SMW139 injection in the severe-relapsing (n = 9) (m), severe acute (n = 6) (n), mild acute (n = 7) (o) EAE, and CFA control (n = 4) (p). S.C. spinal cord, CB cerebellum, B.S. brain stem. (*, p < 0.05; **, p < 0.001; ***, p < 0.0001). Data are expressed as percent injected dose per milliliter (%ID/mL).