Fig. 7
Correlation of the EAE clinical score with the uptake of [11C]SMW139 in the brain and spinal cord and immunohistochemistry staining on spinal cord tissue from EAE animals and controls. Graphs showing the correlation of the difference of [11C]SMW139 uptake between the peak of the EAE disease and the recovery phase with the clinical scores of the same respective animals in the spinal cord (a), cerebellum (b), and brain stem (c). The goodness of the correlation was evaluated using Pearson and Spearman correlation factors and p value for significance. (**, p < 0.001; ***, p < 0.0001). Images showing IBA-1 and CD68 staining on spinal cord tissue from severe EAE rats (d–g), mild EAE rats (h–k), recovery rats (l–o), and CFA control rats (p–s)