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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis

Fig. 2

The course of NfL in experimental PM. a, b At 18 hpi, infected animals displayed non-significantly increased CSF NfL levels (n = 13) compared to mock-infected animals (n = 6), whereas both displayed similar levels in serum NfL (mock-infected n = 16; infected n = 30). At 42 hpi, infected animals showed a significant increase of NfL levels in CSF (n = 22) and serum (n = 28) compared to mock-infected ones (p < 0.0001) (CSF n = 13; serum n = 16). In mock-infected animals, both CSF and serum NfL levels remained stable between 18 and 42 hpi. NfL levels in CSF and serum showed a correlation at 18 hpi (p < 0.05, r = 0.4716; n = 18) (c) and at 42 hpi (p < 0.0001, r = 0.8179; n = 35) (d)

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Journal of Neuroinflammation

ISSN: 1742-2094