Fig. 1

FTS•B counteracted cognitive decline in APP/PS1 mice. (a) In the Morris water maze test, the path tracings were automatically recorded on the testing day. FTS•B reduced (b) the escape latency on the 4 testing days in APP/PS1 mice, as well as (c) the times of crossing the platform on the testing day. (d) The path tracings were automatically recorded in the Y maze test. (e) FTS•B failed to influence training latency, but (f) strongly reduced the testing latency in the Y maze test. (g) The path tracings in the open field test were automatically recorded. (h) FTS•B increased the distance in the surrounding area and (i) reduced the distance in the center area of APP/PS1 mice in the open field test. Data are expressed as the mean ± standard error (n = 8). #p < 0.05, ##p < 0.01, and ###p < 0.001 vs. WT mice. *p < 0.05 and **p < 0.01 vs. APP/PS1 mice. FTS•B, forsythoside B; APP/PS1, amyloid precursor protein/presenilin 1; WT, wild type