Table 2 The effects of FTS•B on cytokines levels in the brains of APP/PS1 mice

TLR3 (ug/g prot)

30.7 ± 2.9

22.7 ± 1.9##

27.6 ± 2.8*

28.3 ± 2.3*

p-IRF3/IRF3

0.2 ± 0.0

0.2 ± 0.0#

0.5 ± 0.1*

0.5 ± 0.1***

IFN-β (ng/g prot)

30.7 ± 3.7

17.3 ± 2.5#

23.4 ± 4.1

26.4 ± 1.9*

JIP3 (ng/g prot)

81.4 ± 17

171.8 ± 35.2#

59.6 ± 21.3*

53.8 ± 10.6**

p-JNK/JNK

7.1 ± 0.6

10 ± 1.0#

5.6 ± 1.1*

5.7 ± 0.7**

p-APP/APP

0.3 ± 0.0

0.6 ± 0.1#

0.2 ± 0.1**

0.2 ± 0.0**

Aβ (mg/g prot)

1.1 ± 0.1

1.5 ± 0.1##

0.9 ± 0.1***

1.2 ± 0.1**

TNF-α (ng/g prot)

2.1 ± 0.1

2.3 ± 0.1#

1.7 ± 0.1***

1.8 ± 0.1**

IL-1β (ng/g prot)

68.4 ± 8.1

113.6 ± 13.1##

82.5 ± 10.8*

75.4 ± 6.4**

IL-6 (ng/g prot)

176.7 ± 4.3

215.7 ± 8.3###

171.2 ± 8.4***

170.4 ± 9.8**

IL-8 (ng/g prot)

96 ± 15.1

177.5 ± 28.1#

96.2 ± 18.5*

105.5 ± 9.1

IL-12 (ng/g prot)

37.6 ± 3.0

56 ± 5.3#

29.7 ± 5.6**

29 ± 4.2**