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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Knockdown of long non-coding RNA SOX2OT downregulates SOX2 to improve hippocampal neurogenesis and cognitive function in a mouse model of sepsis-associated encephalopathy

Fig. 3

Cognitive impairment and SOX2OT and SOX2 upregulation in a mouse model of sepsis-associated encephalopathy. a Escape latency time, b swimming speed, c time spent in the target quadrant, and d number of crossings over the target quadrant in the Morris water maze. e Freezing time in context and f freezing time in response to a cue in the fear conditioning test (n = 15/group). Relative levels of g SOX2OT and h SOX2 mRNAs were measured by RT-qPCR on days 3, 7, and 14 after sham or CLP surgery (n = 5/group). &p < 0.05 vs. day 1 of Morris water maze test; #p < 0.05 vs. Sham; **p < 0.05. Abbreviations: CLP, cecal ligation and perforation; MWM, Morris water maze; SOX2, sex-determining region Y-box 2; SOX2OT, SOX2 overlapping transcript

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Journal of Neuroinflammation

ISSN: 1742-2094